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Impact of open-label versus blinded study design on patient-reported outcomes data in randomized clinical trials of immunotherapy in advanced or metastatic cancer patients: a systematic review.
- Source :
- Quality of Life Research; Mar2022, Vol. 31 Issue 3, p645-657, 13p, 1 Diagram, 6 Charts, 1 Graph
- Publication Year :
- 2022
-
Abstract
- Aim: A systematic literature review of immuno-oncology trials was conducted to assess the potential impact of open-label vs double-blind trial design on patient-reported outcome (PRO) data. Methods: A systematic search of indexed literature published from January 2009 to May 2019 was conducted using PubMed/MEDLINE, Cochrane Library, and EMBASE database. All randomized clinical trials (RCTs) of immuno-oncology therapies on advanced cancer patients reporting PRO data were identified. Descriptive analyses were performed to quantify differences at baseline and over time, by the type of study, regarding questionnaire completion rate and PRO scores. Results: In total, 23 studies were retained (15 open-label, 8 blinded). At baseline, no difference in completion rate was observed between arms irrespective of trial design (absolute mean difference of 2.8% and 2.2% for open label and blinded studies, respectively). No clinically significant difference in baseline PRO scores was observed between arms. Over time, impact on PRO scores could not be identified due to the limited number of studies, heterogeneity of questionnaires and tumor types. Conclusions: Trial design had no impact on PRO completion rate or baseline scores. Future research should involve analyses by specific cancer types and ideally compare individual data from two similar RCTs (blinded vs. open-label). [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of monoclonal antibodies
TUMOR classification
EXPERIMENTAL design
ONLINE information services
PATIENT aftercare
MEDICAL databases
INFORMATION storage & retrieval systems
MEDICAL information storage & retrieval systems
SYSTEMATIC reviews
HEALTH outcome assessment
CANCER patients
RANDOMIZED controlled trials
RESEARCH funding
TUMORS
MEDLINE
RESEARCH bias
DATA analysis software
IMMUNOTHERAPY
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 09629343
- Volume :
- 31
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Quality of Life Research
- Publication Type :
- Academic Journal
- Accession number :
- 155758469
- Full Text :
- https://doi.org/10.1007/s11136-021-02945-8