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Safety and Efficacy of Single-Dose Ketorolac for Postoperative Pain Management After Primary Palatoplasty: A Prospective Cohort Study With Historical Controls.
- Source :
- Cleft Palate Craniofacial Journal; Apr2022, Vol. 59 Issue 4, p505-512, 8p
- Publication Year :
- 2022
-
Abstract
- Objective: To analyze safety and efficacy of single-dose ketorolac after primary palatoplasty (PP). Design: Consecutive cohort of patients undergoing PP, comparing to historical controls. Setting: A large academic children's hospital. Patients, Participants: A consecutive cohort of 111 patients undergoing PP (study n = 47) compared to historical controls (n = 64). Interventions: All patients received intraoperative acetaminophen, dexmedetomidine, and opioids while the study group received an additional single dose of ketorolac (0.5 mg/kg) at the conclusion of PP. Main Outcome Measures: Safety of ketorolac was measured by significant bleeding complications and need for supplementary oxygen. Efficacy was assessed through bleeding, Face Legs Activity Cry Consolability (FLACC) scale, and opioid dose. Results: Length of stay was similar for both groups (control group 38.5 hours [95% CI: 3.6-43.3] versus study group 37.6 hours [95% CI: 31.3-44.0], P =.84). There were no significant differences in all postoperative FLACC scales. The mean dose of opioid rescue medication measured as morphine milligram equivalents did not differ between groups (P =.56). Significant postoperative hemorrhage was not observed. Conclusions: This is the first prospective study to evaluate the safety and efficacy of single-dose ketorolac after PP. Although lack of standardization between study and historical control groups may have precluded observation of an analgesic benefit, analysis demonstrated a single dose of ketorolac after PP is safe. Further investigations with more patients and different postoperative regimens may clarify the role of ketorolac in improving pain after PP. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG efficacy
LENGTH of stay in hospitals
STATISTICAL power analysis
CONFIDENCE intervals
EFFECT sizes (Statistics)
CLEFT palate
HEALTH outcome assessment
FISHER exact test
CLEFT lip
MATHEMATICAL variables
T-test (Statistics)
CHI-squared test
DESCRIPTIVE statistics
DATA analysis software
POSTOPERATIVE pain
KETOROLAC
PAIN management
LONGITUDINAL method
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 10556656
- Volume :
- 59
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Cleft Palate Craniofacial Journal
- Publication Type :
- Academic Journal
- Accession number :
- 155732080
- Full Text :
- https://doi.org/10.1177/10556656211012864