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Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.
- Source :
- Natural Product Research; Mar2022, Vol. 36 Issue 5, p1230-1235, 6p
- Publication Year :
- 2022
-
Abstract
- Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC<subscript>50</subscript> value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- SESQUITERPENES
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 36
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 155689192
- Full Text :
- https://doi.org/10.1080/14786419.2020.1869970