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Evidence of dengue virus in eviscerated specimens of panophthalmitis secondary to dengue fever: A possible cause-effect phenomenon.

Authors :
Dave, Tarjani
Sharma, Savitri
Lakshmi, Vemu
Rangaiahgari, Ashok
Murthy, Somasheila
Ali, Mohammad
Dave, Vivek
Pappuru, Rajeev
Dave, Tarjani V
Murthy, Somasheila I
Ali, Mohammad J
Dave, Vivek P
Pappuru, Rajeev R
Source :
Indian Journal of Ophthalmology; Mar2022, Vol. 70 Issue 3, p965-969, 5p
Publication Year :
2022

Abstract

<bold>Purpose: </bold>To report a retrospective series of three cases of infectious panophthalmitis post-dengue fever with ex vivo confirmation of dengue virusribonucleic acid (RNA) in the tissues of the eye.<bold>Methods: </bold>Four eyes of three patients, who were diagnosed with panophthalmitis following dengue fever and who underwent evisceration, were included. All demographic and clinical data were recorded. The eviscerated samples were subjected to direct microscopy, culture for bacteria, fungi, and parasites, and molecular virology (dengue virus [DENV] NS1-specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay).<bold>Results: </bold>The time from the development of dengue fever to the occurrence of ocular symptoms was 4.33 ± 1.15 (median 5) days. DENV NS1 RNA, suggestive of the presence of the dengue virus, was confirmed in all evisceration specimens (uveal tissue, cornea). All the patients recovered completely from dengue fever and on follow-up had healthy eviscerated sockets.<bold>Conclusion: </bold>Demonstration of the DENV RNA in the eviscerated specimens of panophthalmitis following dengue fever implicates the DENV in the pathophysiology of the ocular infection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03014738
Volume :
70
Issue :
3
Database :
Complementary Index
Journal :
Indian Journal of Ophthalmology
Publication Type :
Academic Journal
Accession number :
155650045
Full Text :
https://doi.org/10.4103/ijo.IJO_1732_21