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Influence of Age and Sex on Clinical and Therapeutic Features of Laryngopharyngeal Reflux.
- Source :
- Otolaryngology-Head & Neck Surgery; Mar2022, Vol. 166 Issue 3, p468-476, 9p
- Publication Year :
- 2022
-
Abstract
- Objective: To explore the influence of age and sex on the clinical presentation and therapeutic response of patients with laryngopharyngeal reflux (LPR). Study Design: Prospective study. Setting: Prospective multicenter study of 271 patients with a diagnosis of LPR confirmed by impedance-pH monitoring. Methods: Patients were prescribed 6 months of diet changes and a combination of pantoprazole and/or alginate depending on the results of their impedance-pH results. The Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were collected at baseline and at 3 and 6 months posttreatment. Data were explored according to sex and age. Results: A total of 237 patients completed the evaluations (138 females). On the RSS, patients of the oldest group (>60 years) had lower symptom scores (throat pain, ear pain, odynophagia, chest pain, tongue burning, nausea, halitosis, and indigestion) and lower quality-of-life scores than younger individuals. RSS and RSA outcomes significantly improved from pretreatment to 3 months posttreatment in all groups. Scores on the RSS and RSA continued to improve from 3 to 6 months posttreatment in the elderly group. Females with LPR had a higher score on the RSS at baseline as compared with males. On the RSS, scores significantly improved after 3 months in males and females; however, they continued to improve from 3 to 6 months in the female group. Conclusion: Age and sex may influence the clinical presentation and pre- to posttreatment evolution of symptoms and findings. Age and sex differences could be considered in future therapeutic approaches to guide more effective personalized treatment plans for patients with LPR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01945998
- Volume :
- 166
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Otolaryngology-Head & Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 155553026
- Full Text :
- https://doi.org/10.1177/01945998211020284