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A multifunctional α-Fe2O3@PEDOT core–shell nanoplatform for gene and photothermal combination anticancer therapy.
- Source :
- Journal of Materials Chemistry B; 3/7/2022, Vol. 10 Issue 9, p1453-1462, 10p
- Publication Year :
- 2022
-
Abstract
- Exploration of versatile nanoplatforms within one single nanostructure for multidisciplinary treatment modalities, especially achieving a synergistic therapeutic efficacy of combinational gene/photothermal cancer therapy is still a great challenge in biomedicine and nanotechnology. In this study, a unique photothermal nanocarrier has successfully been designed and developed for a combination of gene therapy (GT) and photothermal therapy (PTT) of cancer cells. Surface-engineered iron oxides (α-Fe<subscript>2</subscript>O<subscript>3</subscript>) nanoparticles (NPs) with poly(3,4-ethylenedioxythiophene) (PEDOT) polymer coatings are synthesized using a one-pot in situ oxidative polymerization method. The results show that the as-prepared α-Fe<subscript>2</subscript>O<subscript>3</subscript>@PEDOT core–shell NPs with a uniform particle size exhibit positively charged surfaces, facilitating efficient siRNA Bcl-2 (B-cell lymphoma-2) uptake for delivery to breast cancer cells. More importantly, α-Fe<subscript>2</subscript>O<subscript>3</subscript>@PEDOT core–shell NPs not only display good biocompatibility and water dispersibility but also strong optical absorption enhancement in the Vis-NIR region as compared to α-Fe<subscript>2</subscript>O<subscript>3</subscript> NPs. The obtained α-Fe<subscript>2</subscript>O<subscript>3</subscript>@PEDOT core–shell NPs show an efficient photothermal conversion efficacy (η = 54.3%) and photostability under NIR laser irradiation. As a result, both in vitro and in vivo biological studies on two types of breast cancer cells/tumors treated with α-Fe<subscript>2</subscript>O<subscript>3</subscript>@PEDOT-siRNA nanocomplexes demonstrate high cancer cell apoptosis and tumor inhibition induced by synergistic GT/PTT therapy under mild conditions compared to an individual GT or PTT alone. Taken together, this is the first example of the use of an α-Fe<subscript>2</subscript>O<subscript>3</subscript>@PEDOT core–shell nanoagent as a siRNA delivery nanocarrier for highly effective gene/photothermal combination anticancer therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 10
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 155515401
- Full Text :
- https://doi.org/10.1039/d1tb02625a