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Mouse models of patent ductus arteriosus (PDA) and their relevance for human PDA.

Authors :
Yarboro, Michael T.
Gopal, Srirupa H.
Su, Rachel L.
Morgan, Thomas M.
Reese, Jeff
Source :
Developmental Dynamics; Mar2022, Vol. 251 Issue 3, p424-443, 20p
Publication Year :
2022

Abstract

The ductus arteriosus (DA) is a unique fetal vascular shunt, which allows blood to bypass the developing lungs in utero. After birth, changes in complex signaling pathways lead to constriction and permanent closure of the DA. The persistent patency of the DA (PDA) is a common disorder in preterm infants, yet the underlying causes of PDA are not fully defined. Although limits on the availability of human DA tissues prevent comprehensive studies on the mechanisms of DA function, mouse models have been developed that reveal critical pathways in DA regulation. Over 20 different transgenic models of PDA in mice have been described, with implications for human DA biology. Similarly, we enumerate 224 human singleā€gene syndromes that are associated with PDA, including a small subset that consistently feature PDA as a prominent phenotype. Comparison and functional analyses of these genes provide insight into DA development and identify key regulatory pathways that may serve as potential therapeutic targets for the management of PDA. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10588388
Volume :
251
Issue :
3
Database :
Complementary Index
Journal :
Developmental Dynamics
Publication Type :
Academic Journal
Accession number :
155484991
Full Text :
https://doi.org/10.1002/dvdy.408