Regional development of high-grade gliomas: the anatomical conundrum of cancer biology.

The article informs that High-grade glioma represents a challenge for the medical community worldwide. The new World Health Organization classification tried to explain the biological behavior of these tumors, analyzing their metabolic and genetic pathways. The anatomical factors like neuronal and glial subtypes, lateralized gene-expression, spatiotemporal committed stem cells and extracellular composition explain the biological diversity of gliomas and predict their invasiveness.