Antibacterial activity of Padina australis extract tablet against Escherichia coli.

Padina australis (P. australis) is one of the seaweed that have a potential as antibacterial Escherichia coli (E. coli). Triterpenoids and steroids are secondary metabolites compounds contained in seaweed, and has a variety of activities as bactericide, and hypo-allergenic. This study aims to establish tablet formulation and determine the activity and effectiveness against E.coli bacteria causing diarrheal disease. The formulation was prepared with these treatment: formula I (20 %), formula II (25 %), formula III (30 %), formula IV as negative control in the form of tablet with no active ingredient, and a positive control using amoxycillin (10 ppm). The activity and effectiveness was tested by calculating diameter of inhibition zone-a clear zone resulting from the three formulas, negative, and positive control using Kirby-Bauer method. The result shows that the formulation with active ingredient of 30 % of P. australis extract has an inhibitory activity of 7.7 mm and effective as antibacterial E. coli. Thus it can be concluded that the formulation of 30 % of P. australis extract tablet is the most effective formula as antibacterial E. coli causing diarrhea disease. [ABSTRACT FROM AUTHOR]