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Visible-light-promoted catalyst-/additive-free synthesis of aroylated heterocycles in a sustainable solvent.
- Source :
- Green Chemistry; 2/21/2022, Vol. 24 Issue 4, p1732-1737, 6p
- Publication Year :
- 2022
-
Abstract
- A general visible-light-induced catalyst-/additive-free strategy was developed for the construction of various aroylated heterocycles (55 examples, up to 95% yield, including modification of pharmaceuticals and natural products) such as thioflavones, benzimidazo[2,1-a]isoquinolin-6(5H)-ones, indolo[2,1-a]isoquinolin-6(5H)ones, quaternary 3,3-dialkyl 2-oxindoles, quinoxalin-2(1H)-ones, and benzo[e][1,2,3]oxathiazine 2,2-dioxides in a green solvent (dimethyl carbonate) under air and room temperature conditions. This practical acylation process was achieved using 4-acyl-1,4-dihydropyridines (acyl-DHPs) as acylating reagents under mild conditions, avoiding the use of catalysts, bases, additional oxidants, and traditional organic solvents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 24
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 155357632
- Full Text :
- https://doi.org/10.1039/d1gc04218a