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Immunity to measles in Italian children and adolescents: a persistent problem in view of measles elimination.
- Source :
- Journal of Public Health; Dec2021, Vol. 43 Issue 4, pe601-e609, 9p
- Publication Year :
- 2021
-
Abstract
- Background Despite efforts to increase coverage by two doses of measles vaccine in Italy, measles continues to circulate, with over 13 000 cases of disease since 2013. This study aimed to evaluate immunity to measles in Italian children and adolescents. Methods A total of 378 serum samples from subjects aged 9 months–18 years were collected in Northern, Central and Southern regions of Italy between 2012 and 2016. Specific IgG antibodies against measles were measured by a commercial ELISA kit. Results The frequency of IgG-positive samples ranged from 10.5% in infants under 1 year to 98.3% in children aged 6–7 years. The frequency of IgG was 72.2% in subjects aged 1–2 years, 85.6% in those aged 3–5 years and 88.3 and 86.8% in those aged 8–10 and 11–18 years, respectively. In Northern Italy, IgG prevalence was consistent with data on vaccination coverage, whereas some differences were observed in samples from subjects aged more than 8 years in Central and Southern Italy. Conclusions Our findings confirm that a large proportion of children and adolescents in Italy are still susceptible to measles. While data on first- and second-dose measles vaccination are essential, they are not sufficient to identify susceptible population cohorts to be targeted by vaccination. [ABSTRACT FROM AUTHOR]
- Subjects :
- MEASLES prevention
VACCINATION
RESEARCH
SEROPREVALENCE
KRUSKAL-Wallis Test
STATISTICS
NONPARAMETRIC statistics
MEASLES
IMMUNOGLOBULINS
HEALTH services accessibility
CONFIDENCE intervals
SERODIAGNOSIS
VIRAL load
AGE distribution
HEALTH status indicators
QUANTITATIVE research
MANN Whitney U Test
POPULATION geography
VACCINE effectiveness
IMMUNITY
ENZYME-linked immunosorbent assay
DISEASE susceptibility
DISEASE prevalence
DESCRIPTIVE statistics
MEASLES vaccines
STATISTICAL sampling
DATA analysis software
DATA analysis
LOGISTIC regression analysis
CHILDREN
ADOLESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 17413842
- Volume :
- 43
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 155321757
- Full Text :
- https://doi.org/10.1093/pubmed/fdaa153