Synthesis of Bifunctional Silica Container Particles on Antiseptic Micelles with Solubilized Curcumin and Assessment of Their Biological Activity.

The features of the synthesis of SiO₂ mesoporous container particles (MCPs) using a hybrid template represented by miramistin micelles with curcumin solubilized in them have been studied. Miramistin is an antiseptic, whereas curcumin is a hydrophobic biologically active compound of a broad range of action. The effects of reaction system pH on the structure and morphology of MCPs and on the content of the biologically active compounds in them have been investigated. It has, in particular, been found that spherical and rodlike MCPs are formed in neutral and alkaline media, respectively. Quantitative data have been obtained on the kinetics of releasing the encapsulated compounds from the container particles into an ambient medium with a given pH value. It has been determined that the rate of this process can additionally be controlled by forming a shell a biocompatible polymer, polydopamine, on the MCP surface. Using MCPs synthesized in an alkaline medium as an example, it has been shown that such containers are highly efficient antiseptics with respect to both gram-positive and gram-negative microorganisms. [ABSTRACT FROM AUTHOR]