Back to Search Start Over

Validation and comparison of prognostic scales in Chinese patients with ischemic stroke: a prospective study from CATIS.

Validation and comparison of prognostic scales in Chinese patients with ischemic stroke: a prospective study from CATIS.

Authors :
Zhang, Kaixin
Zhu, Zhengbao
Che, Bizhong
Bu, Xiaoqing
Xu, Tian
Zhong, Chongke
Wang, Aili
Peng, Hao
Guo, Daoxia
Zheng, Xiaowei
Xu, Tan
Chen, Jing
Zhang, Yonghong
He, Jiang
Source :
Neurological Research; Feb 2022, Vol. 44 Issue 2, p97-103, 7p
Publication Year :
2022

Abstract

: Various tools are currently available to quantify the risks of adverse clinical outcomes after an ischemic stroke. This study aimed to validate and compare prognostic scales among Chinese patients with ischemic stroke. : We compared three stroke prognostic scales (Stroke Prognostication using Age and the National Institutes of Health Stroke Scale-100 [SPAN-100], Totaled Health Risks in Vascular Events [THRIVE], and Acute Stroke Registry and Analysis of Lausanne [ASTRAL]) in 3870 Chinese patients with ischemic stroke from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The 2-year primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3). : Among all the scales, the ASTRAL score had the best accuracy for predicting 2-year prognosis in Chinese patients with ischemic stroke. The C-statistic of the ASTRAL score for the 2-year primary outcome was 0.79 (95% confidence interval [CI]: 0.78–0.80), and the Hosmer–Lemeshow goodness-of-fit test showed that the ASTRAL score fitted Chinese patients with ischemic stroke well (χ<superscript>2</superscript> = 9.83, P = 0.277). The incidences of the primary outcome in the <5%, 5%–9.9%, 10%–19.9%, and ≥20% risk groups based on the ASTRAL scores were 3.93%, 7.55%, 14.29%, and 41.81%, respectively (odds ratio: 1.23; 95% CI: 1.21–1.26; P < 0.001). : The ASTRAL score had higher efficacy than the SPAN-100 and THRIVE scores in predicting 2-year adverse outcomes among Chinese patients with ischemic stroke, suggesting that it could be a valuable risk assessment tool for the 2-year prognosis of such patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01616412
Volume :
44
Issue :
2
Database :
Complementary Index
Journal :
Neurological Research
Publication Type :
Academic Journal
Accession number :
155180998
Full Text :
https://doi.org/10.1080/01616412.2021.1959775