Back to Search
Start Over
Racial disparities in bone metastasis patterns and targeted screening and treatment strategies in newly diagnosed lung cancer patients.
- Source :
- Ethnicity & Health; Feb 2022, Vol. 27 Issue 2, p329-342, 14p, 4 Charts, 1 Graph
- Publication Year :
- 2022
-
Abstract
- Objective: Race disparities exist in bone metastasis (BM) development and survival in lung cancer (LC) patients. The Surveillance, Epidemiology, and End Results (SEER) database was used to investigate different patterns of BM development and survival in different races. Design: LC patients with BM were identified from the database from 2010 to 2014. Risk factors were investigated by univariable and multivariable logistic regression. Potential factors for prognosis were evaluated by univariable and multivariable Cox regression. Results: Asian and Pacific Islander (API) patients presented the highest prevalence of BM (24.6%), followed by white (20.7%) and black patients (19.9%) (χ2 = 78.74; p <.001). After adjusting for the demographic and clinical factors, API race was independently associated with a high risk of BM development. The median survival times for the API, white and black LC patients with BM were 16 months (95% CI: 15.2–16.8), 11 months (95% CI: 10.9–11.1) and 10 months (95% CI: 9.7–10.3), respectively, with significant differences (p <.001). Multivariable Cox regression showed that API race was positively associated with greater overall survival compared with white and black patients. Male gender, larger tumor size, lymph node involvement, lower tumor differentiated grade, and the presence of lung, liver and brain metastases were independently associated with a high risk of developing BM and worse survival with LC across all races. Age, income, insurance and histological types had different impacts on BM among different races. Conclusion: Homogeneous and heterogeneous associated factors for BM were revealed among different races. Individualized screening and treatment should be performed race-specifically. [ABSTRACT FROM AUTHOR]
- Subjects :
- RACISM
PUBLIC health surveillance
STATISTICS
HEALTH services accessibility
CONFIDENCE intervals
MULTIPLE regression analysis
HEALTH status indicators
EARLY detection of cancer
LUNG tumors
LYMPH nodes
QUANTITATIVE research
CANCER patients
TUMOR classification
INCOME
BONE metastasis
SURVIVAL analysis (Biometry)
DISEASE prevalence
DESCRIPTIVE statistics
CHI-squared test
KAPLAN-Meier estimator
WHITE people
STATISTICAL correlation
PROPORTIONAL hazards models
INSURANCE
Subjects
Details
- Language :
- English
- ISSN :
- 13557858
- Volume :
- 27
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Ethnicity & Health
- Publication Type :
- Academic Journal
- Accession number :
- 155144867
- Full Text :
- https://doi.org/10.1080/13557858.2020.1734775