Abnormal levels of cortisol and cortisone in patients with prurigo nodularis.

The article presents the discussion on Prurigo nodularis (PN) being a highly pruritic condition caused by a vicious circle of repeated itching. Topics include showing severer symptoms of anxiety and depression than healthy control group and also having a higher prevalence of anxiety and depression; and limited data available on investigating the hypothalamic-pituitary-gonadal (HPG) axis activity in skin diseases.