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Two new diterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata.
- Source :
- Natural Product Research; Feb 2022, Vol. 36 Issue 3, p814-821, 8p
- Publication Year :
- 2022
-
Abstract
- Two new diterpenoids, penicichrysogene A (1) and penicichrysogene B (2), were isolated from the solid substrate fermentation cultures of Penicillium chrysogenum MT-12, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR, UV, IR, and HRESIMS). The absolute configurations of 1 and 2 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compound 1 exhibited inhibitory activity on ATP release of thrombin-activated platelets with IC<subscript>50</subscript> = 42.7 ± 3.5 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 36
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 154902500
- Full Text :
- https://doi.org/10.1080/14786419.2020.1808637