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Molecular features of glioblastomas in long-term survivors compared to short-term survivors-a matched-pair analysis.
- Source :
- Radiation Oncology; 1/24/2022, Vol. 17 Issue 1, p1-8, 8p
- Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>Although glioblastoma (GB) is associated with a devastating prognosis, a small proportion of patients achieve long-term survival rates. We herein present a matched-pair analysis of molecular factors found in long- and short-term survivors (LTS, STS).<bold>Methods: </bold>We performed a cross-institutional analysis of 262 patient records and matched a group of 91 LTS (≥ 3 years) with two groups of STS (STS-1, n = 91; STS-2, n = 80). Matching was performed according to age, Karnofsky Performance Status, initial therapy and adjuvant therapy. Molecular factors were compared between LTS (total of 91 patients) v. STS-1, and LTS (subgroup of 80 patients) v. STS-2. We included glial fibrillary acidic protein (GFAP), O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, isocitrate dehydrogenase 1 (IDH-1); furthermore, the proliferation index was analyzed (Ki-67/MIB-1).<bold>Results: </bold>IDH-1 and decreased Ki-67 were numerically associated with LTS but the difference was only significant compared to STS-1 (n.s. v. STS-2). LTS was associated with MGMT promoter hypermethylation (p = 0.013 and p = 0.022) and GFAP expression (p < 0.001 and p = 0.001). Positivity for both factors combined compared to negativity for one factor occurred more often in the LTS group (p = 0.002 and p = 0.006); negativity for both factors combined did not occur in the LTS group.<bold>Conclusion: </bold>In this retrospective analysis, GFAP expression and MGMT promoter methylation were associated with LTS. Given the hypothesis-generating nature of our study, these observations should be confirmed in prospective clinical trials. [ABSTRACT FROM AUTHOR]
- Subjects :
- GLIAL fibrillary acidic protein
O6-Methylguanine-DNA Methyltransferase
KARNOFSKY Performance Status
GLIOBLASTOMA multiforme
ISOCITRATE dehydrogenase
PROTEINS
RESEARCH
DNA
TIME
RESEARCH methodology
GLIOMAS
RETROSPECTIVE studies
PAIRED comparisons (Mathematics)
CYTOSKELETAL proteins
EVALUATION research
COMPARATIVE studies
ENZYMES
GENES
RESEARCH funding
QUESTIONNAIRES
Subjects
Details
- Language :
- English
- ISSN :
- 1748717X
- Volume :
- 17
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 154871020
- Full Text :
- https://doi.org/10.1186/s13014-022-01984-w