Association between an increase in blood urea nitrogen at 24 h and worse outcomes in COVID-19 pneumonia.

Cumulative incidence for in-hospital death of patients with coronavirus disease 2019 subgrouped by BUN value at admission and BUN change in 24 h. (A) Increase BUN versus no increase BUN at 24 h. (B) Increase BUN versus no increase BUN at 24 h when BUN at admission was normal (<20 mg/dL). Patients with increased BUN had higher proportion of hypertension and COPD history and lower LYM, albumin and globulin level. In pairwise comparison, patients with increase delta BUN had significant lower overall survival rate than patients with no increase delta BUN in normal admission BUN group (<20 mg/dL) and abnormal admission group (>=20 mg/dL) (Figure 1(B,C)). The mean delta BUN was 1.0 mg/dL (SD 9.5 mg/dL), with 206 patients (77.4%) experiencing a decrease or no change in BUN and 60 patients (22.6%) experiencing an increase. [Extracted from the article]