СУБКЛІНІЧНЕ ЗАПАЛЕННЯ ПРИ НЕАЛКОГОЛЬНІЙ ЖИРОВІЙ ХВОРОБІ ПЕЧІНКИ У ВІДДАЛЕНОМУ ПЕРІОДІ ПІСЛЯ ЧОРНОБИЛЬСЬКОЇ АВАРІЇ.

Objective: to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholic fatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors. Materials and methods. Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result of the Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parameters and the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxidative modification of lipids and proteins was evaluated. Results. Activation of the processes of oxidative modification of lipids and proteins was observed in most patients with NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developing complicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratio correlates positively with hsCRP and can be used as an available routine clinical marker for selection among patients with NAFLD persons with increased risk of cardiovascular complications. Conclusions. HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used to assess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with con& comitant cardiovascular disease. [ABSTRACT FROM AUTHOR]