ANTI-RENAL DISORDER ACTIVITY OF BIOSYNTHESIS SELENIUM NANOPARTICLES AGAINST ALLOXAN-INDUCED KIDNEY INJURY IN MALE RATS.

The present study reports that garlic (Allium sativum) has the potentiality to reduce sodium selenite and synthesize selenium nanoparticles. The exposure of aqueous sodium selenite to the Allium sativum abstract leads to the synthesis of stable selenium nanoparticles within seven days. The colorless appearance of the reaction medium was turned to red color indicates the process of reduction. The mechanism of reduction was analyzed through UV-Visible (UV-Vis) Spectrophotometer, the spectrum showed major peak at 29 nm. Fourier Transform Infra-Red Spectroscopic (FT-IR) analysis substantiated the existence of bonds for the organic contents of garlic extract and to find out the crystallite size and miller indices; x ray diffraction (XRD) was also mentioned in this paper. This biogenic synthesis is a cost effective, simple and ecofriendly method. Kidney injury is a clinical syndrome associated with the incidence of rhabdomyolysis. The current study was carried out to evaluate whether selenium nanoparticles can protect against the alloxan-induced kidney injury. Rats were randomly divided into six groups (n=7) and then the experimental processes conducted for thirty days, the results proved that SeNPs reduced the biochemical and histological changes produced by alloxan. And in general, they could be used to protect against kidney disorder development via antioxidant, anti-inflammatory and anti-apoptotic activities. [ABSTRACT FROM AUTHOR]