CANINE ADIPOSE-DERIVED MESENCHYMAL STEM CELL THERAPY IN GERMAN SHEPHERD DOG OSTEOARTHRITIS : A REVIEW.

Osteoarthritis (OA) in dogs is a disease with a small cure value and a high pain level. German Shepherd Dogs (SGD) suffering from OA will experience limitations in assisting police and military duties. Various therapies using drugs have been carried out and cause side effects. Treatment using canine adipose-derived mesenchymal stem cell (cAD-MSC) has the potential to provide effective and safe healing in OA dogs. This review was done to describe the potential of Canine adiposederived mesenchymal stem cells in German Shepherd Dogs in providing healing in cases of Osteoarthritis. Intraauricular therapy was more effective in treating OA in German Shepherd Dogs than intravenously. Expression of CD44, CD73, CD90 and CD29 in cAD-MSC has potential in chondrogenic differentiation into adipocytes, osteocytes, osteoblasts, and chondrocytes. In conclusion, cAD-MSC may cure for German Shepherd Dogs suffering from Osteoarthritis. Intraauricular cAD-MSC therapy has the potential to cure Osteoarthritis in German Shepherd Dogs. The effectiveness of the cAD-MSC therapy method on autologous or allogeneic German Shepherd Osteoarthritis still needs further research. [ABSTRACT FROM AUTHOR]