Analysis of the rule of medication of compound Chinese traditional patent medicine for digestive system tumors based on data mining.

Objective: Based on the data mining method, explore the medication rules of Chinese patent medicines for the treatment of digestive system tumors. Method: Based on the "Chinese Traditional Medicine Prescription Database" in https://db.yaozh.com/, collect Chinese patent medicines for the treatment of digestive system tumors, establish an Excel table, and use the ancient and modern medical case cloud platform (V2.2.1) to perform frequency statistics, association rules, and drugs on the data Clustering and complex network analysis. Results: A total of 36 Chinese patent medicines for the treatment of digestive system tumors were screened. The medicinal properties were mainly warm and cold, the taste was bitter and sweet, and the meridians were mainly liver and spleen meridians. High frequency Chinese medicine include Astragalus, Scutellaria-barbata, Ginseng, Curcuma, Triangle, Atractylodes, Hedyotis diffusa, etc. Correlation analysis obtained 17 drug combinations, High-frequency drug pairs include Scutellaria-barbata-Astragalus, Ginseng-Astragalus, Curcuma-Astragalus, Scutellaria-barbata-Curcuma, etc. Cluster analysis found 3 types of drugs. The core drug network is composed of 27 drugs, and the core compatibility network consists of 3 groups of drugs. Conclusion: The Chinese patent compound medicine for the treatment of digestive system tumors has the characteristics of combining cold and warming, replenishing and reducing treatment, and treating the liver and spleen at the same time. The medicine is mainly used to replenish qi and invigorate the spleen, promote blood circulation and remove blood stasis, and clear away heat and detoxification. Replenish qi, nourish yin, invigorate blood, and detoxify are mainly compatible with each other, reflecting the pathogenesis characteristics of "deficiency, stasis, and toxin" in digestive system tumors. Data mining can provide references for the prescription and compatibility of Chinese patent medicines. [ABSTRACT FROM AUTHOR]