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Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications.
- Source :
- Stem Cells International; 1/6/2022, p1-23, 23p
- Publication Year :
- 2022
-
Abstract
- Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1687966X
- Database :
- Complementary Index
- Journal :
- Stem Cells International
- Publication Type :
- Academic Journal
- Accession number :
- 154541178
- Full Text :
- https://doi.org/10.1155/2022/2454168