Back to Search
Start Over
Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection.
- Source :
- Journal of Infectious Diseases; 1/1/2022, Vol. 225 Issue 1, p172-176, 5p
- Publication Year :
- 2022
-
Abstract
- Pertussis, caused by Bordetella pertussis, is a reemerging disease that can produce severe disease manifestations in infants, including pulmonary hypertension (PH). B. pertussis-induced PH is a major risk factor for infection-induced death, but the molecular mechanisms promoting PH are unknown and there is no effective treatment. We examined B. pertussis-induced PH in infant and adult mouse models of pertussis by Fulton index, right heart catheterization, or Doppler echocardiogram. Our results demonstrate that B. pertussis-induced PH is age related and dependent on the expression of pertussis toxin by the bacterium. Hence, pertussis toxin-targeting treatments may ameliorate PH and fatal infant infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- PERTUSSIS toxin
BORDETELLA pertussis
PULMONARY hypertension
LABORATORY mice
INFANTS
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 225
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 154512141
- Full Text :
- https://doi.org/10.1093/infdis/jiab325