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Biotin interference: evaluation of an updated thyroglobulin electrochemiluminescent immunoassay.
- Source :
- Clinical Chemistry & Laboratory Medicine; Jan2022, Vol. 60 Issue 2, pe46-e49, 4p
- Publication Year :
- 2022
-
Abstract
- Keywords: biotin; ECLIA; immunoassay; method evaluation; thyroglobulin EN biotin ECLIA immunoassay method evaluation thyroglobulin e46 e49 4 01/07/22 20220115 NES 220115 To the Editor, Biotin interference in immunoassays is well-known and researched [[1]]. Exogenous biotin disturbs this interaction, potentially causing falsely decreased results for sandwich immunoassays, such as the Elecsys SP ® sp thyroglobulin (Tg) assay (Roche Diagnostics, Switzerland) [[4]]. Plasma peak concentrations induced by OTC supplements (53-141 ng/mL) or by treatment with high biotin doses (up to 1,160 ng/mL plasma levels) do not exceed the biotin threshold of the Tg2New assay insert or our experimentally confirmed threshold [[1]]. [Extracted from the article]
- Subjects :
- THYROGLOBULIN
BIOTIN
IMMUNOASSAY
GRAVES' disease
Subjects
Details
- Language :
- English
- ISSN :
- 14346621
- Volume :
- 60
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical Chemistry & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 154506958
- Full Text :
- https://doi.org/10.1515/cclm-2021-0969