Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients.

<bold>Background: </bold>To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.<bold>Methods: </bold>This study consisted of two parts, each part included 3 groups, namely dry eye without AE group, dry eye with AE group and pre-clinical dry eye with AE group. In part 1, we studied the variations of Schirmer I test and six tear compositions before and after AE (34 eyes in each group). In part 2, we studied the variations of tear meniscus height, first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness, number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity before and after AE (30 eyes in each group).<bold>Results: </bold>In dry eye with AE group, Schirmer I test at 0 min after AE increased significantly compared to baseline (P < 0.001), the oxidative stress marker 8-hydroxy-2'-deoxyguanosine after AE decreased significantly compared to baseline (P = 0.035, P = 0.045), F-NITBUT and A-NITBUT after AE prolonged significantly compared to baseline (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 min after AE decreased significantly compared to baseline (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001). Besides, significant differences were also found between dry eye with AE group and dry eye without AE group at all above corresponding time point (P < 0.05).<bold>Conclusion: </bold>AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.<bold>Trial Registration: </bold>Chinese Clinical Trial Registry, ChiCTR2000038673 . Registered 27 September 2020. [ABSTRACT FROM AUTHOR]