Opening up to cAMP Transport Mechanisms in Airway Smooth Muscle.

The authors discuss a study by G. Cao and colleagues which used primary human airway smooth muscle cells from tracheas in observational and mechanistic experimental approaches to characterize the expression and function of ABCC1. Topics include the earliest asthma medications reported, cytoskeleton properties of human airway smooth muscle cells, and a discussion on major translational findings of ABCC1 function as a cAMP exporter in human airway smooth muscle.