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Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease.

Authors :
Lipskaia, Larissa
Maisonnasse, Pauline
Fouillade, Charles
Sencio, Valentin
Pascal, Quentin
Flaman, Jean-Michel
Born, Emmanuelle
London-Vallejo, Arturo
Le Grand, Roger
Bernard, David
Trottein, François
Adnot, Serge
Source :
American Journal of Respiratory Cell & Molecular Biology; Jan2022, Vol. 66 Issue 1, pE1-E5, 7p
Publication Year :
2022

Abstract

The article provides information on a study on the effect of SARS-CoV-2 on lung-cell senescence. Topics discussed include differential gene-expression analysis performed using model-based analysis of single-cell transcriptomics (MAST), expression of senescence markers, and histopathology and immunohistochemistry.

Details

Language :
English
ISSN :
10441549
Volume :
66
Issue :
1
Database :
Complementary Index
Journal :
American Journal of Respiratory Cell & Molecular Biology
Publication Type :
Academic Journal
Accession number :
154450402
Full Text :
https://doi.org/10.1165/rcmb.2021-0205le