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Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network.
- Source :
- Virulence; Dec 2021, Vol. 12 Issue 1, p679-689, 11p
- Publication Year :
- 2021
-
Abstract
- Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieitis virus and Madin-Darby Bovine Kidney cells were used as the modeling virus and cell line, respectively. CAP was shown to create synergies with virus infection in arresting host cells at the G2/M stage, decreasing cell membrane potential, increasing intracellular calcium level, and inducing selective autophagy. In addition, CAP was demonstrated to suppress virus-triggered immunogenic signaling as evaluated by IRF7 expression. We presented evidences on CAP-triggered maximization of host resources toward virus multiplication that is advantageous for viral vaccine production, and opened a novel regime for applying CAP in the sector of medical care and health. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21505594
- Volume :
- 12
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Virulence
- Publication Type :
- Academic Journal
- Accession number :
- 154362511
- Full Text :
- https://doi.org/10.1080/21505594.2021.1883933