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Olive oil effectively mitigates ovariectomy-induced marrow adiposity assessed by MR spectroscopy in estrogen-deficient rabbits.
- Source :
- Acta Radiologica; Feb2022, Vol. 63 Issue 2, p245-252, 8p
- Publication Year :
- 2022
-
Abstract
- Background: Polyphenols in extra virgin olive oil (EVOO) have been found to reduce the expression of PPARĪ³2, inhibit adipocyte differentiation, and enhance the formation of osteoblasts from bone marrow stem cells. However, the underlying mechanisms of their action remain unknown. Purpose: To determine the sequential effects of EVOO on marrow fat expansion induced by estrogen deprivation using 3.0-T proton magnetic resonance (MR) spectroscopy in an ovariectomy (OVX) rabbit model of postmenopausal bone loss over a six-month period. Material and Methods: A total of 45 female New Zealand rabbits were equally divided into sham-operation, OVX controls, and OVX treated with EVOO for six months. Marrow fat fraction was measured by MR spectroscopy at baseline conditions, and three and six months postoperatively, respectively. Serum bone biomarkers, lumbar and femoral bone mineral density, microtomographic parameters, biomechanical properties, and quantitative parameters of marrow adipocytes were studied. Results: OVX was associated with marrow adiposity in a time-dependent manner, accompanied with increased bone turnover and impaired bone mass and trabecular microarchitecture. In OVX rabbits, EVOO markedly alleviated trabecular bone loss and reduced the accumulation of lipid droplets including adipocyte size, density, and areas of fat deposits in the bone marrow. EVOO prevented such changes in terms of both marrow adiposity and bone remodeling. Conclusion: Early EVOO treatment may exert beneficial effects on bone by modulating marrow adiposity, which would support their protective effect against bone pathologies. [ABSTRACT FROM AUTHOR]
- Subjects :
- OLIVE oil
BONE marrow cells
PROTON magnetic resonance spectroscopy
BONE marrow
BONE density
PROTON magnetic resonance
THERAPEUTIC use of olive oil
BIOMARKERS
ANIMAL experimentation
NUCLEAR magnetic resonance spectroscopy
RABBITS
OSTEOPOROSIS
TOMOGRAPHY
OVARIECTOMY
FAT cells
DESCRIPTIVE statistics
BIOMECHANICS
ADIPOSE tissues
Subjects
Details
- Language :
- English
- ISSN :
- 02841851
- Volume :
- 63
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Acta Radiologica
- Publication Type :
- Academic Journal
- Accession number :
- 154361067
- Full Text :
- https://doi.org/10.1177/0284185120986937