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ZFTA‐YAP1 fusion‐positive ependymoma can occur in the spinal cord: Letter to the editor.

Authors :
Lim, Ka Young
Lee, Kwang Hoon
Phi, Ji Hoon
Yun, Hongseok
Won, Jae Kyung
Choi, Seung Hong
Park, Sung‐Hye
Source :
Brain Pathology; Jan2022, Vol. 32 Issue 1, p1-5, 5p
Publication Year :
2022

Abstract

MPE, myxopapillary ependymoma; PFA-EPN, posterior fossa group A ependymoma; PFB-EPN, posterior fossa group B ependymoma; PF-SUBEPN, posterior fossa-subependymoma; PN, ependymoma; SP-EPN, spinal-ependymoma; SP-SUBEPN, spinal subependymoma; ST-EPN-ZFTA, supratentorial-ependymoma ZFTA fusion-positive; ST-SUBEPN, supratentorial subependymoma; YAP1-EPN, ST-ependymoma YAP1-positive gl Our case might be the first case of SP-EPN harboring a I ZFTA-YAP1 i fusion. ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor Although I ZFTA i fusion-positive EPN occurs mainly in the supratentorial region, one I ZFTA i - I RELA i fusion-positive EPN in the cerebellum and one I ZFTA i - I MAML2 i fusion-positive EPN in the cervical junction have been reported [9]. Unsupervised t-SNE analysis with an overlay on the known ependymal tumor clusters revealed that our case belonged to ST-EPN- I RELA i (now the same as I ZFTA i -fusion-positive ST-EPN), not SP-EPN. [Extracted from the article]

Details

Language :
English
ISSN :
10156305
Volume :
32
Issue :
1
Database :
Complementary Index
Journal :
Brain Pathology
Publication Type :
Academic Journal
Accession number :
154358418
Full Text :
https://doi.org/10.1111/bpa.13020