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Th17 Lymphocytes in Children with Asthma: Do They Influence Control?
- Source :
- Pediatric Allergy, Immunology & Pulmonology; Dec2021, Vol. 34 Issue 4, p147-152, 6p
- Publication Year :
- 2021
-
Abstract
- Background: Allergic asthma was considered as an inflammation mediated by specific CD4<superscript>+</superscript> helper lymphocytes (Th2); however, this paradigm changed in 2005, when a third group of helper cells called Th17 cells were identified. Th17 lymphocytes are the main source of interleukin (IL)-17A–F, IL-21, and IL-22; however, their physiological role in children is unclear. This study aimed to determine the percentage of Th17 cells and IL-17A in pediatric patients diagnosed with asthma and to associate it with disease control using a validated questionnaire. Methods: This cross-sectional, prospective, comparative study included 92 asthma-diagnosed children 4–18 years of age. The Asthma Control Test was used as an assessment measure to classify patients as controlled (n = 30), partially controlled (n = 31), and uncontrolled (n = 31). Th17 cells and IL-17A were analyzed by flow cytometry. Patients receiving inhaled steroid therapy as monotherapy or associated with a long-acting bronchodilator were included. Results: The mean percentage of Th17 cells in the participants was 4.55 ± 7.34 (Controlled), 5.50 ± 8.09 (Partially Controlled), and 6.14 ± 7.11 (Uncontrolled). There was no significant difference between the 3 groups (P = 0.71). The mean percentage of IL-17A in all the participants was 9.84 ± 9.4 (Controlled), 10.10 ± 10.5 (Partially Controlled), and 11.42 ± 8.96 (Uncontrolled); no significant difference between the 3 groups (P = 0.79) was observed. Th17 lymphocyte levels were similar among the 3 groups and the same trend was observed with IL-17A. A significant correlation between Th17 or IL-17A and the degree of asthma control (Th17, P = 0.24; IL-17A, P = 0.23) was not found. Conclusions: The percentages of both Th17 lymphocytes and IL-17A found in children with asthma were not significantly different in the 3 groups, which suggests that they do not play an important role in asthma control. Our findings may contribute to the knowledge related to non-Th2 inflammation in children. Clinical-Trials.gov ID: 2015-2102-85. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG therapy for asthma
STEROID drugs
INTERLEUKINS
FLOW cytometry
KRUSKAL-Wallis Test
STATISTICS
ASTHMA
ANALYSIS of variance
CROSS-sectional method
ASTHMA in children
COMPARATIVE studies
BRONCHODILATOR agents
SYMPTOMS
DESCRIPTIVE statistics
QUESTIONNAIRES
T cells
INHALATION administration
DATA analysis software
DATA analysis
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 2151321X
- Volume :
- 34
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Pediatric Allergy, Immunology & Pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 154335864
- Full Text :
- https://doi.org/10.1089/ped.2021.0067