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Suicide attempt induced by drug‐induced leukoencephalopathy: A case report.

Suicide attempt induced by drug‐induced leukoencephalopathy: A case report.

Authors :
Maehara, Ryo
Kawamata, Yasushi
Ichikawa, Motoshi
Mitani, Kinuko
Yasui‐Furukori, Norio
Shimoda, Kazutaka
Source :
Neuropsychopharmacology Reports; Dec2021, Vol. 41 Issue 4, p551-553, 3p
Publication Year :
2021

Abstract

Background: Leukoencephalopathy is identified during the administration of anticancer drugs. Symptoms vary from neurological symptoms to psychiatric symptoms depending on the site of damage. There have been no previous reports of suicide attempts due to drug‐induced leukoencephalopathy. Case Presentation: The patient was diagnosed with diffuse large B‐cell lymphoma (DLBCL) infiltrating the pharyngeal lesion. Rituximab + methotrexate + oncovin + procarbazine (R‐MPV) therapy, a methotrexate‐containing chemotherapy, was initiated. At the end of the fifth course, the patient attempted suicide by hanging with an appliance cord, which was associated with delusion. A head MRI scan showed no evidence of lymphoma recurrence, but white matter lesions around the ventricles showed progression. Conclusion: We report the case of a patient in whom drug‐induced leukoencephalopathy related to methotrexate led to a suicide attempt. In addition to monitoring brain tumors, daily monitoring of psychiatric and neurological symptoms is important for patients with methotrexate‐induced encephalopathy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2574173X
Volume :
41
Issue :
4
Database :
Complementary Index
Journal :
Neuropsychopharmacology Reports
Publication Type :
Academic Journal
Accession number :
154293305
Full Text :
https://doi.org/10.1002/npr2.12214