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A comparative study of microneedling combined with topical 5-fluorouracil versus microneedling alone in treatment of localized stable vitiligo.
- Source :
- Indian Journal of Dermatology; Sep/Oct2021, Vol. 66 Issue 5, p574-574, 1p
- Publication Year :
- 2021
-
Abstract
- Context: Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules, and patches. Aims: To compare the therapeutic efficacy and safety of microneedling combined with topical 5-fluorouracil solution versus microneedling alone on stable patches of vitiligo. Settings and Design: Hospital-based interventional prospective study. Methods and Material: We selected 46 patients in the age group of 10–50 years having patch stability of at least 1-year duration. The patients were randomly assigned into two groups of 23 patients each. Group A was treated with microneedling followed by application of 5-fluorouracil which was available in the form of a solution (50 mg/mL) whereas Group B was treated with microneedling alone. The procedure was repeated after every 15 days up to 4 months and patient follow-up along with the grading of repigmentation was done till 6 months. The side effects were noted. Statistical Analysis Used: Statistical Package for Social Sciences (SPSS) software, version 25.0. The results were analyzed using the Chi-square test and t-test and P < 0.05 was considered significant. Results: At the end of 6 months, excellent response (>75% repigmentation) was reported in 35 patches (48.6%) in Group A treated with microneedling combined with 5-fluorouracil whereas only 12 patches (16.9%) showed an excellent response in Group B treated with microneedling alone. Conclusions: Combining microneedling with 5-fluorouracil is a simple, safe, well tolerable, and effective modality than microneedling alone for treating small localized vitiligo patches. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00195154
- Volume :
- 66
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Indian Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 154230276
- Full Text :
- https://doi.org/10.4103/ijd.ijd_130_21