Primary cutaneous anaplastic large‐cell lymphoma with marked spontaneous regression of organ manifestation after SARS‐CoV‐2 vaccination.

Thoracic computed tomography (CT) showed innumerable bilateral pulmonary nodules that were suspicious for new pcALCL manifestation or second malignancy (Figure 1g). Notably, 10-42% of patients diagnosed with pcALCL may experience spontaneous remission.1 We detected identical clonal T-cell receptor gamma-chain rearrangements in lung lesions and previous skin lesions, together proving that the pulmonary lesions very likely originated from pcALCL. Dear Editor, Primary cutaneous anaplastic large-cell lymphoma (pcALCL) belongs to the primary cutaneous CD30+ T-cell lymphoproliferative disorders.1 Systemic involvement is relatively rare and pcALCL is generally confined to the regional lymph nodes.1 In this research letter, we describe a patient with recurrent pcALCL and diffuse lung manifestation that spontaneously regressed after one SARS-CoV-2 vaccination. [Extracted from the article]