Back to Search
Start Over
Validation analysis of a composite real-world mortality endpoint for patients with cancer in the United States.
- Source :
- Health Services Research; Dec2021, Vol. 56 Issue 6, p1281-1287, 7p, 3 Charts
- Publication Year :
- 2021
-
Abstract
- Objective: We expanded the previous assessment of a mortality variable suited for real-world evidence-focused oncology research. Data source: We used a nationwide electronic health record (EHR)-derived de-identified database. Data collection: We included patients with at least 1 of 18 cancer types between January 1, 2011 and December 31, 2017. Patient-level structured data (EHRs, obituaries, and Social Security Death Index) and unstructured EHR data (abstracted) were linked to generate a composite mortality variable. Study design: We benchmarked sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and ±15-day agreement against the National Death Index (NDI). Real-world overall survival (rwOS) was estimated using the Kaplan-Meier method. We performed sensitivity analyses using a smaller patient cohort that underwent next-generation sequencing testing. Principal findings: Compared with the NDI across 18 cancer types (overall N = 160 436): sensitivity, 83.9%-91.5% (17/18 cancer types had sensitivity ≥85.0%); specificity, 93.5%-99.7%; PPV, 96.3%-98.3%; NPV, 75.0%-98.7%; ±15-day agreement, 95.6%-97.6%; and median rwOS estimates ranging from 2.8% to 12.7% greater. Sensitivity analysis results (n = 17 540) were consistent with the main analysis. Conclusions: Across all cancer types analyzed, this composite mortality variable showed high sensitivity, specificity, PPV, NPV, and ±15-day agreement, and yielded median rwOS values modestly overestimated when compared to NDI-based results. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00179124
- Volume :
- 56
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Health Services Research
- Publication Type :
- Academic Journal
- Accession number :
- 154195414
- Full Text :
- https://doi.org/10.1111/1475-6773.13669