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Development of Polymer-Based Nanoformulations for Glioblastoma Brain Cancer Therapy and Diagnosis: An Update.

Authors :
Rabha, Bijuli
Bharadwaj, Kaushik Kumar
Pati, Siddhartha
Choudhury, Bhabesh Kumar
Sarkar, Tanmay
Kari, Zulhisyam Abdul
Edinur, Hisham Atan
Baishya, Debabrat
Atanase, Leonard Ionut
Source :
Polymers (20734360); Dec2021, Vol. 13 Issue 23, p4114, 1p
Publication Year :
2021

Abstract

Brain cancers, mainly high-grade gliomas/glioblastoma, are characterized by uncontrolled proliferation and recurrence with an extremely poor prognosis. Despite various conventional treatment strategies, viz., resection, chemotherapy, and radiotherapy, the outcomes are still inefficient against glioblastoma. The blood–brain barrier is one of the major issues that affect the effective delivery of drugs to the brain for glioblastoma therapy. Various studies have been undergone in order to find novel therapeutic strategies for effective glioblastoma treatment. The advent of nanodiagnostics, i.e., imaging combined with therapies termed as nanotheranostics, can improve the therapeutic efficacy by determining the extent of tumour distribution prior to surgery as well as the response to a treatment regimen after surgery. Polymer nanoparticles gain tremendous attention due to their versatile nature for modification that allows precise targeting, diagnosis, and drug delivery to the brain with minimal adverse side effects. This review addresses the advancements of polymer nanoparticles in drug delivery, diagnosis, and therapy against brain cancer. The mechanisms of drug delivery to the brain of these systems and their future directions are also briefly discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734360
Volume :
13
Issue :
23
Database :
Complementary Index
Journal :
Polymers (20734360)
Publication Type :
Academic Journal
Accession number :
154081869
Full Text :
https://doi.org/10.3390/polym13234114