Thermocycle and Evolutionary Combinatorics of Macromolecules: the Basis of Primary Processes of the Origin of Life.

The paper is devoted to the problems of the life origin, the study of which was launched by the Academician E.M. Galimov. E.M. Galimov is a scientist with a wide range of research interests, a deep understanding of fundamental natural processes, a researcher with a remarkable intuition. Numerous considerations and discussions of one of the authors of the article, S.D. Varfolomeev with the Аcademician E.M. Galimov resulted in the formulation of a concept providing a natural-scientific explanation of the origin of life. The basic kinetic principles of the nucleation and evolution of protobiopolymeric molecules are considered. Our approach involves the processes of polymerization and selection of macromolecular structures and is based on thermocycle, which provides the thermodynamic possibility of the formation of a monomer–monomer bond and kinetic selection of structures through a choice of more statutory complexes. Kinetic modeling and analysis of obtained solutions demonstrated the possibility of exponential growth of all protopolymers of the system and the formation of possible interpolymer complexes representing the prototypes of ribosome-type cellular organelles. The possibility of the emergence of life having a fundamentally different chemical basis under nonterrestrial conditions is considered. [ABSTRACT FROM AUTHOR]