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Resorcinol derivatives with α-glucosidase inhibitory activities from Syzygium samarangense.
- Source :
- Natural Product Research; Dec 2021, Vol. 35 Issue 24, p5948-5953, 6p
- Publication Year :
- 2021
-
Abstract
- Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca−8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves of Syzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Among them, compounds 3, 4, 6 and 7 exhibited significant α-glucosidase inhibitory activities with IC<subscript>50</subscript> of 3.16, 3.16, 2.34 and 0.99 µM, respectively. This finding provides evidence that resorcinol derivatives with long aliphatic chain function as new promising antidiabetic alternatives. [ABSTRACT FROM AUTHOR]
- Subjects :
- RESORCINOL
SYZYGIUM
HYPOGLYCEMIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 24
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 153986162
- Full Text :
- https://doi.org/10.1080/14786419.2020.1805606