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Increased hippocampal DNA oxidation in serotonin transporter deficient mice.
- Source :
- Journal of Neural Transmission; May2002, Vol. 109 Issue 5/6, p557-565, 9p
- Publication Year :
- 2002
-
Abstract
- Summary. The serotonin transporter (5HTT) is the molecule responsible for the high-affinity reuptake of 5HT from the synaptic cleft. Mice lacking the 5HTT exhibit highly elevated extracellular concentrations of 5HT. We assessed whether the glutathione detoxification system is altered in 5HTT-deficient mice. While levels of reduced and oxidized glutathione were unchanged, glutathione metabolising enzymes showed a differential pattern of modulation. Glutathione peroxidase was reduced in frontal cortex, brainstem, and cerebellum of 5HTT-deficient mice, though not to a statistically significant extent, while a putative isoform of the detoxifying enzyme glutathione-S-transferase pi was decreased in a number of brain regions, especially in brainstem. At the level of the DNA, we found an increase of oxidative DNA adducts in the hippocampus of 5HTT-deficient mice. Given the importance of the hippocampus in learning and memory, this may be the most important neurochemical consequence of the absence of the 5HTT. [ABSTRACT FROM AUTHOR]
- Subjects :
- SEROTONIN
GLUTATHIONE transferase
DNA
OXIDATION
NEURAL transmission
LABORATORY mice
Subjects
Details
- Language :
- English
- ISSN :
- 03009564
- Volume :
- 109
- Issue :
- 5/6
- Database :
- Complementary Index
- Journal :
- Journal of Neural Transmission
- Publication Type :
- Academic Journal
- Accession number :
- 15397231