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Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines.
- Source :
- Microorganisms; Nov2021, Vol. 9 Issue 11, p2245-2245, 1p
- Publication Year :
- 2021
-
Abstract
- We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011–2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017–2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20762607
- Volume :
- 9
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Microorganisms
- Publication Type :
- Academic Journal
- Accession number :
- 153897353
- Full Text :
- https://doi.org/10.3390/microorganisms9112245