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Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.

Authors :
Redenbaugh, Vyanka
Montalvo, Mayra
Sechi, Elia
Buciuc, Marina
Fryer, James P.
McKeon, Andrew
Lennon, Vanda A.
Mills, John R.
Weinshenker, Brian G.
Wingerchuk, Dean M.
Chen, John J.
Tariq Bhatti, M.
Lopez Chiriboga, A. Sebastian
Pittock, Sean J.
Flanagan, Eoin P.
Source :
Multiple Sclerosis Journal - Experimental, Translational & Clinical; 11/26/2021, p1-5, 5p
Publication Year :
2021

Abstract

Objective: Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD). Methods: We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria. Results: Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive. Conclusions: AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20552173
Database :
Complementary Index
Journal :
Multiple Sclerosis Journal - Experimental, Translational & Clinical
Publication Type :
Academic Journal
Accession number :
153895193
Full Text :
https://doi.org/10.1177/20552173211052656