Back to Search
Start Over
Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.
- Source :
- Multiple Sclerosis Journal - Experimental, Translational & Clinical; 11/26/2021, p1-5, 5p
- Publication Year :
- 2021
-
Abstract
- Objective: Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD). Methods: We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria. Results: Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive. Conclusions: AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEUROMYELITIS optica
IMMUNOGLOBULIN G
AQUAPORINS
MEDICAL records
Subjects
Details
- Language :
- English
- ISSN :
- 20552173
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal - Experimental, Translational & Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 153895193
- Full Text :
- https://doi.org/10.1177/20552173211052656