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In vitro α-glycosidase and urease enzyme inhibition profile of some selected medicinal plants of Pakistan.
- Source :
- Natural Product Research; Dec 2021, Vol. 35 Issue 23, p5434-5439, 6p
- Publication Year :
- 2021
-
Abstract
- The current study aims at exploring enzyme inhibition of four species of medicinal herbs, namely Senna bicapsularis, Thevetia peruviana, Nerium oleander and Vinca major. Plant selection was done on the basis of their therapeutic uses by local practitioners. The crude methanolic extracts of these plants were tested for their α-glycosidase and urease enzyme inhibition potential. The observed urease inhibitory potential for the crude extract of S. bicapsularis, T. peruviana and N. oleander were 8.3 ± 0.33 μg, 6.98 ± 0.98 μg and 9.56 ± 1.43 μg, respectively while the V. major did not show any inhibition. In addition, the IC<subscript>50</subscript> value for Thiourea was 22.3 ± 1.14 μg. The crude extracts of S. bicapsularis, T. peruviana, N. oleander, V. major were shown to inhibit α-glycosidase activity with an IC<subscript>50</subscript> value of 630.3 ± 0.03 μg, 700.7 ± 2.43 μg, 430.4 ± 3.97 μg, and the standard (acarbose) 880 ± 1.03 μM, respectively. Based on the TLC profile, the extract of S. bicapsularis was subjected to column chromatography and the major component named rhein (1) was identified. Compound 1 exhibited excellent urease and α-glycosidase inhibitory activity with an IC<subscript>50</subscript> value of 7.4 ± 0.32 and 622.3 ± 1.03 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- UREASE
MEDICINAL plants
GLYCOSIDASES
OLEANDER
ENZYMES
PLANT selection
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 153878865
- Full Text :
- https://doi.org/10.1080/14786419.2020.1779264