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High-pressure asymmetric hydrogenation in a customized flow reactor and its application in multi-step flow synthesis of chiral drugs.
- Source :
- Journal of Flow Chemistry; Dec2021, Vol. 11 Issue 4, p763-772, 10p
- Publication Year :
- 2021
-
Abstract
- Asymmetric homogeneous hydrogenation under high pressure in continuous flow was achieved with a slug flow reactor. High hydrogen pressure enabled iridium-catalyzed asymmetric hydrogenation of acetophenone with a turn-over-frequency (TOF) of up to 274,000 h<superscript>−1</superscript>. An operando infrared tool was used to provide in-situ monitoring of the reaction. The effect of gas-liquid ratio and speed of slug flow in the microchannel were studied. The multi-step flow synthesis of active pharmaceutical ingredients, in which asymmetric hydrogenation is a key step, was successfully demonstrated, with subsequent reactions carried out under longer residence times within a cascade of CSTRs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2062249X
- Volume :
- 11
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Flow Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153849155
- Full Text :
- https://doi.org/10.1007/s41981-021-00143-8