Construction of a Cu(II)-Based Coordination Polymer: Photocatalytic Performance and Prevention Activity on Hypertension.

On the basis of 1,3,5-tris(2-methylimidazol-1-yl)benzene (timb) ligand, a designed tripodal connector, a new coordination polymer (CP) containing Cu(II) ions as nodes has been generated by reaction between timb ligand and Cu(NO₃)₂·3H₂O in the presence of the second carboxylate ligand 5-Br-isophthalic acid (Br-H₂IPA), and its chemical formula is {[Cu₄(timb)₂(Br–IPA)₄]·5H₂O}_n (1). Furthermore, due to its excellent framework stability in water, complex 1 possesses high photocatalytic effects for the methylene blue (MB) degradation under the irradiation of UV light, and its process of photodegradation is chiefly resulted from the radical ·OH radicals. Its application values on the hypertension were assessed, simultaneously, its detailed mechanism could be investigated. The blood pressure meter was used in this research to evaluate the blood pressure of the animals. The real time reverse transcription-polymerase chain reaction (RT-PCR) was accomplished and the Vitamin D (VitD) receptor expression levels against the vascular endothelial cells. Molecular docking simulation demonstrated that both imidazole and carboxyl groups were found to be active to the active sites from target protein Vitamin D. [ABSTRACT FROM AUTHOR]