Back to Search
Start Over
Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems.
- Source :
- Natural Product Research; Nov 2021, Vol. 35 Issue 22, p4849-4852, 4p
- Publication Year :
- 2021
-
Abstract
- Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pre-treated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABA<subscript>A</subscript>, GABA<subscript>B</subscript>, 5-HT<subscript>1A</subscript>, 5-HT<subscript>3</subscript>, α<subscript>1</subscript>, α<subscript>2</subscript>, and D<subscript>2</subscript> receptors. [ABSTRACT FROM AUTHOR]
- Subjects :
- GABA agents
ADRENERGIC receptors
RESEARCH teams
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 153688787
- Full Text :
- https://doi.org/10.1080/14786419.2020.1737052