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Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis.
- Source :
- Clinical Rheumatology; Apr2004, Vol. 23 Issue 2, p129-133, 5p
- Publication Year :
- 2004
-
Abstract
- Antiphospholipid antibodies (aPL) are a heterogeneous family of antibodies associated with thrombotic events and other complications. The objective of this study was to investigate the prevalence of aPL in a group of Chilean patients with thrombosis. Two hundred and twenty-six patients with venous and arterial thrombosis and 95 healthy controls were studied. Anticardiolipin (aCL), anti-β<subscript>2 </subscript>glycoprotein I (anti-β<subscript>2</subscript>GPI), and antiprothrombin (aPT) antibodies were determined. Eighty-eight out of 226 (38.9%) patients with thrombosis had some type of aPL. Fifty-seven patients (25.2%) were positive for aCL, 31 (13.7%) for aPT, and 14 (6.2%) for anti-β<subscript>2</subscript>GPI antibodies. Twelve patients (5.3%) were positive for more than one aPL. IgG, IgM and IgA isotypes were observed in aCL, anti-β<subscript>2</subscript>GPI, and aPT antibodies. Twenty-six out of 92 (28.3%) patients with venous thrombosis and 31/134 (23.1%) patients with arterial thrombosis were positive for aCL antibodies. With regard to the control group (4/95=4.2%), the odd ratios (OR) were 5.2 (1.3–19.8; p0.01) and 5.7 (1.6–22.3; p0.01), respectively. Additionally, we observed statistically significant OR with aPT and anti-β<subscript>2</subscript>GPI antibodies; in the first, with venous and arterial thrombosis, and in the second, only with arterial thrombosis. Our results show a significant prevalence of aPL, predominantly aCL and aPT antibodies, in patients with thrombosis. Additionally, aCL and aPT antibodies appear to be a risk factor for venous and arterial thrombosis, and anti-β<subscript>2</subscript>GPI antibodies appear to be a risk factor for arterial thrombosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHOSPHOLIPID antibodies
AUTOANTIBODIES
VENOUS thrombosis
THROMBOSIS
GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 07703198
- Volume :
- 23
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 15361043
- Full Text :
- https://doi.org/10.1007/s10067-003-0846-7