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Barriers and potential solutions in the recruitment and retention of older patients in clinical trials—lessons learned from six large multicentre randomized controlled trials.
- Source :
- Age & Ageing; Nov2021, Vol. 50 Issue 6, p1988-1996, 9p, 1 Chart, 4 Graphs
- Publication Year :
- 2021
-
Abstract
- Background older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients. Objective to identify key barriers and to discuss solutions to specific issues affecting recruitment and retention of older participants in clinical trials based on experience gained from six current European randomised controlled trials (RCTs) focusing on older people. Methods a multidisciplinary group of experts including representatives of the six RCTs held two networking conferences and compiled lists of potential barriers and solutions. Every item was subsequently allocated points by each study team according to how important it was perceived to be for their RCTs. Results the six RCTs enrolled 7,612 older patients. Key barriers to recruitment were impaired health status, comorbidities and diverse health beliefs including priorities within different cultural systems. All trials had to increase the number of recruitment sites. Other measures felt to be effective included the provision of extra time, communication training for the study staff and a re-design of patient information. Key barriers for retention included the presence of severe comorbidities and the occurrence of adverse events. Long study duration, frequent study visits and difficulties accessing the study site were also mentioned. Solutions felt to be effective included spending more time maintaining close contact with the participants, appropriate measures to show appreciation and reimbursement of travel arrangements. Conclusion recruitment and retention of older patients in trials requires special recognition and a targeted approach. Our results provide scientifically-based practical recommendations for optimizing future studies in this population. [ABSTRACT FROM AUTHOR]
- Subjects :
- HUMAN research subjects
PATIENT participation
CLINICAL trials
PATIENT selection
TIME
CONFERENCES & conventions
HEALTH status indicators
RANDOMIZED controlled trials
BUSINESS networks
INTERPROFESSIONAL relations
HEALTH attitudes
HEALTH
INFORMATION resources
PATIENT-professional relations
EMOTIONS
COMORBIDITY
PERSONNEL management
COMMUNICATION education
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 00020729
- Volume :
- 50
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Age & Ageing
- Publication Type :
- Academic Journal
- Accession number :
- 153609863
- Full Text :
- https://doi.org/10.1093/ageing/afab147