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The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 11/12/2021, p1-13, 13p, 7 Graphs
- Publication Year :
- 2021
-
Abstract
- The effects of Curcuma longa (C. longa) on total and differential WBC, inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed. Animals were divided to 5 groups including control (C), asthma (sensitized to ovalbumin), and asthmatic groups treated with 0.75, 1.50, and 3.00 mg/ml C. longa (CL) and 1.25 μg/ml dexamethasone (D) (8 rats in each group). Total and differential WBC count, concentrations of phospholipase A<subscript>2</subscript> (PLA<subscript>2</subscript>), total protein (TP), interferon-gamma (IFN-γ), interleukin-4 (IL-4), immunoglobulin E (IgE), NO<subscript>2</subscript>, NO<subscript>3</subscript>, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and thiol in BALF were assessed. Total and most differential WBC counts and BALF levels of PLA<subscript>2</subscript>, TP, IgE, IL-4, and oxidants in asthma group were higher but antioxidants and IFN-γ levels as well as IFN-γ/IL-4 ratio were lower than control group (p < 0.001 for all cases). Total WBC and levels of PLA<subscript>2</subscript>, IgE, NO<subscript>2</subscript>, and NO<subscript>3</subscript> were significantly reduced following treatment with C. longa, compared to asthma group (p < 0.001 for all cases). In groups treated with dexamethasone and two higher concentrations of C. longa, neutrophil and eosinophil counts as well as TP, IL-4, and MDA levels were significantly decreased but IFN-γ, IFN-γ/IL-4 ratio, and antioxidants were increased (except IFN-γ/IL-4 ratio), compared to asthma group (p < 0.05 to p < 0.001). Compared to dexamethasone, C. longa exerted more pronounced effects on lung inflammation, oxidative stress, and immune system in asthmatic rats. [ABSTRACT FROM AUTHOR]
- Subjects :
- SULFUR compounds analysis
DRUG therapy for asthma
PROTEIN analysis
NITROGEN oxide analysis
IMMUNOGLOBULIN analysis
LUNG disease treatment
BIOMARKERS
INTERLEUKINS
EOSINOPHILS
BRONCHOALVEOLAR lavage
ANIMAL experimentation
LEUCOCYTES
DEXAMETHASONE
PHOSPHOLIPASES
ANTIOXIDANTS
OXIDIZING agents
SUPEROXIDE dismutase
RATS
INTERFERONS
MALONDIALDEHYDE
CATALASE
NEUTROPHILS
OXIDATIVE stress
COMPARATIVE studies
TREATMENT effectiveness
IMMUNOLOGICAL adjuvants
DESCRIPTIVE statistics
PLANT extracts
INFLAMMATORY mediators
IMMUNOLOGIC diseases
DATA analysis software
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 153550923
- Full Text :
- https://doi.org/10.1155/2021/4234326