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Persistence of the SARS-CoV-2 Antibody Response in Asymptomatic Patients in Correctional Facilities.
- Source :
- Frontiers in Microbiology; 11/10/2021, Vol. 12, p1-7, 7p
- Publication Year :
- 2021
-
Abstract
- SARS-CoV-2 has caused a global health disaster with millions of death worldwide, and the substantial proportion of asymptomatic carriers poses a huge threat to public health. The long-term antibody responses and neutralization activity during natural asymptomatic SARS-CoV-2 infection are unknown. In this study, we used enzyme-linked immunosorbent assays (ELISA) and neutralization assay with purified SARS-CoV-2S and N proteins to study the antibody responses of 156 individuals with natural asymptomatic infection. We found robust antibody responses to SARS-CoV-2 in 156 patients from 6 to 12 months. Although the antibody responses gradually decreased, S-IgG was more stable than N-IgG. S-IgG was still detected in 79% of naturally infected individuals after 12 months of infection. Moderate to potent neutralization activities were also observed in 98.74% of patients 6 months after infection. However, this proportion decreased at 8-month (46.15%) and 10-month (39.11%) after infection, respectively. Only 23.72% of patients displayed potent neutralization activity at 12 months. This study strongly supports the long-term presence of antibodies against SARS-CoV-2 in individuals with natural asymptomatic infection, although the magnitude of the antibody responses started to cripple 6 months after infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIBODY formation
SARS-CoV-2
ENZYME-linked immunosorbent assay
Subjects
Details
- Language :
- English
- ISSN :
- 1664302X
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Frontiers in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 153503588
- Full Text :
- https://doi.org/10.3389/fmicb.2021.789374